Large-scale MRI analysis identifies specific brain regions acting as epicenters of atrophy in multiple sclerosis patients.
Key Details
- 1Study analyzed MRI scans from 2,187 multiple sclerosis patients.
- 2Researchers observed grey matter atrophy originating from cortical 'disease epicenters'.
- 3The nodal stress hypothesis suggests highly connected hubs are more vulnerable to atrophy.
- 4Epicenters included visual, sensorimotor, temporal cortices, hippocampi, thalami, and amygdala.
- 5Transneuronal degeneration was observed, spreading neurodegeneration along network connections.
- 6Network-based MRI measures may help predict atrophy progression independently of inflammation or relapses.
Why It Matters
Understanding patterns and mechanisms of atrophy in MS via MRI aids in targeting disease progression and personalizing care. These findings may inform future imaging biomarkers and computational models for tracking neurodegeneration in MS.
Source
EurekAlert
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