
Radiologists and leading AI models struggle to distinguish AI-generated deepfake X-ray images from authentic radiographs, according to a recent Radiology journal study.
Key Details
- 1Study involved 264 X-ray images, half real and half generated by AI models, including ChatGPT-4o and RoentGen.
- 217 radiologists from six countries participated, with accuracy in identifying deepfake images ranging from 58% to 92%.
- 3Four leading multimodal LLMs (GPT-4o, GPT-5, Gemini 2.5 Pro, Llama 4 Maverick) had detection accuracies between 52% and 89%.
- 4No correlation was found between years of radiology experience and accuracy; musculoskeletal specialists performed better than others.
- 5Common AI-deepfake X-ray features included overly smooth bones, symmetric lungs, and unnaturally straight spines.
- 6Proposed safeguards include invisible watermarks and cryptographic image signatures.
Why It Matters

Source
EurekAlert
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