ChatGPT-5 missed about half of distal radius fractures on x-rays, showing limited diagnostic capability in a real-world scenario.
Key Details
- 1Study evaluated ChatGPT-5 using the Stanford MURA dataset: 370 anteroposterior wrist x-rays with 45.9% fracture prevalence.
- 2ChatGPT-5 was given a simple yes/no prompt to detect fractures via its public web interface (zero-shot, no additional context).
- 3The model had 51.2% sensitivity, 70.5% specificity, and 61.6% overall accuracy for fracture detection.
- 4ChatGPT-5 missed 83 fractures and had more false negatives than false positives (McNemar χ²=4.06, p=0.044).
- 5Authors caution that general-purpose LLMs should not be used as standalone diagnostic tools for fracture detection.
Why It Matters

Source
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