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ChatGPT-5 Performs Poorly at Detecting Distal Radius Fractures on X-rays

AuntMinnieIndustry

ChatGPT-5 missed about half of distal radius fractures on x-rays, showing limited diagnostic capability in a real-world scenario.

Key Details

  • 1Study evaluated ChatGPT-5 using the Stanford MURA dataset: 370 anteroposterior wrist x-rays with 45.9% fracture prevalence.
  • 2ChatGPT-5 was given a simple yes/no prompt to detect fractures via its public web interface (zero-shot, no additional context).
  • 3The model had 51.2% sensitivity, 70.5% specificity, and 61.6% overall accuracy for fracture detection.
  • 4ChatGPT-5 missed 83 fractures and had more false negatives than false positives (McNemar χ²=4.06, p=0.044).
  • 5Authors caution that general-purpose LLMs should not be used as standalone diagnostic tools for fracture detection.

Why It Matters

This study highlights the limitations of using general-purpose LLMs like ChatGPT-5 for medical imaging diagnosis, underscoring the need for model adaptation, specific prompt engineering, and rigorous radiologist benchmarking before clinical use in radiology workflows.

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