An AI tool accurately detected structural heart disease from smartwatch single-lead ECGs in a 600-person prospective trial.
Key Details
- 1AI model was trained using 266,000 12-lead ECGs from 110,000 patients and validated on large external cohorts.
- 2Prospective real-world testing was performed with 600 adults using smartwatch-recorded single-lead ECGs.
- 3Algorithm achieved 88% accuracy (AUC) in smartwatch data; sensitivity was 86% and negative predictive value 99%.
- 4Diseases detected included weakened pumping, valve damage, or thickened heart muscle—most commonly found with cardiac ultrasound (echo).
- 5Preliminary results were presented at AHA Scientific Sessions 2025 and have not yet been peer-reviewed.
Why It Matters
Wearable devices leveraging AI may democratize early detection of serious heart conditions, traditionally requiring advanced imaging. This signals a potential paradigm shift in accessible screening workflows, informing radiology and cardiology practice.

Source
EurekAlert
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