<sup>18</sup>F-FDG PET/CT in multiple myeloma: A brief review.
Authors
Affiliations (1)
Affiliations (1)
- 2nd Academic Department of Nuclear Medicine, University General Hospital AHEPA, Thessaloniki, Greece. [email protected].
Abstract
<sup>18</sup>F-FDG PET/CT plays an important role in multiple myeloma (MM) by providing functional information that complements anatomical assessment. Its clinical applications extend from disease detection and baseline prognostic evaluation to treatment response and minimal residual disease (MRD) assessment. <sup>18</sup>F-FDG PET/CT findings such as focal lesion burden, intensity of <sup>18</sup>F-FDG uptake, paramedullary (PMD) and extramedullary disease (EMD) have been associated with adverse outcomes, while metabolic response during or following treatment provides robust prognostic information. <sup>18</sup>F-FDG PET/CT also complements bone marrow-based MRD assessment by detecting residual disease outside the biopsy site. However, false-positive and false-negative findings, together with incomplete standardisation of quantitative parameters, can complicate interpretation. Novel PET radiotracers and artificial intelligence (AI)-based quantitative approaches are currently under investigation. This review summarises the current role of <sup>18</sup>F-FDG PET/CT in MM, with emphasis on initial diagnosis and disease extent evaluation, prognostic value, treatment response and MRD assessment, limitations and future perspectives.