Integration of imaging and clinical biomarkers for cerebral infarction diagnosis via NeuroFusionNet.
Authors
Affiliations (6)
Affiliations (6)
- Department of Neurology, The First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, China.
- Henan Medical Key Laboratory of Neurology, The First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, China.
- Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, The First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, China.
- Henan Key Laboratory of Neurorestoratology and Protein Modification, The First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, China.
- Department of Rehabilitation, The First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, China.
- Department of Radiology, The First Affiliated Hospital of Henan Medical University, Xinxiang, Henan, China.
Abstract
Cerebral infarction remains a leading cause of mortality and long-term disability worldwide, demanding rapid and accurate diagnostic strategies. However, current assessments primarily rely on imaging interpretation, often neglecting valuable clinical and laboratory information that could enhance diagnostic precision. We developed NeuroFusionNet, a multi-modal deep learning framework that integrates imaging features with clinical biomarkers for binary classification of cerebral infarction and healthy controls. The model combines a ResNet-based visual encoder with a multilayer perceptron branch for clinical indicators, achieving end-to-end feature fusion and joint optimization. NeuroFusionNet achieved superior diagnostic performance with an accuracy of 0.9655, precision of 0.9584, recall of 0.9584, and F1-score of 0.9584, significantly outperforming baseline models including ResNet, MobileNet, and GhostNet. The integration of imaging and clinical biomarkers effectively enhanced model sensitivity and robustness, demonstrating strong potential for real-world clinical application. Our findings highlight the clinical value of integrating imaging and laboratory data for precision diagnosis of cerebral infarction. NeuroFusionNet provides a scalable and interpretable framework that may support early detection and personalized management of cerebrovascular diseases in routine clinical practice.