Accelerated Brain Aging in Type 1 Diabetes Across Painful and Painless Peripheral Neuropathy: MRI-Based Brain Age Estimates From Deep Learning.
Authors
Hostrup SNF,Croosu SS,Røikjer J,Mørch CD,Brock C,Drewes AM,Brock B,Muthulingam JA,Hansen TM,Ejskjaer N,Frøkjær JB
Affiliations (8)
Affiliations (8)
- Radiology Research Center, Department of Radiology, Aalborg University Hospital, Aalborg, Denmark.
- Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
- Steno Diabetes Center North Denmark, Aalborg University Hospital, Aalborg, Denmark.
- Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark.
- Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.
- Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg Hospital, Aalborg university Hospital.
- Steno Diabetes Center Copenhagen, Region Hovedstaden, Gentofte, Denmark.
- Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.
Abstract
Accelerated brain aging has been reported in diabetes, but its links with diabetic peripheral neuropathy (DPN) and neuropathic pain remain unclear. We explored brain age gap (BAG) in type 1 diabetes to determine if it differs across neuropathic phenotypes, relates to clinical characteristics including DPN measures, and shows distinct regional patterns. Diabetes participants had 3.5 years of BAG, rising to 6-7 years in those with DPN. Diabetes duration was the main driver of BAG, whereas DPN had limited impact and neuropathic pain no clear contribution. BAG was widespread across the brain. Accelerated brain aging appears to affect people with diabetes regardless of neuropathic complications.
Topics
Journal Article