SUITPy: A Python-based toolbox for the analysis of cerebellar functional and anatomical imaging data across the human lifespan.
Authors
Affiliations (6)
Affiliations (6)
- Western Institute for Neuroscience, Western University, London, ON, Canada.
- Department of Computer Science, Western University, London, ON, Canada.
- Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands.
- Faculty of Computer Science, Dalhousie University, Halifax, Canada.
- Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom.
- Department of Psychology, Western University, London, ON, Canada.
Abstract
The human cerebellum plays a central role in motor, emotional, and cognitive functions, and is implicated in many brain disorders. To improve the analysis of functional and anatomical imaging from the cerebellum, we introduce SUITPy, an improved and fully revised Python implementation of the widely used SUIT toolbox. For this new version, we developed a U-Net based model to automatically isolate the cerebellum from adjacent cortical tissue, which achieves higher fidelity than existing algorithms. The isolation works robustly without manual corrections for imaging data across the lifespan. We show that isolation and subsequent normalization to a cerebellum-only template lead to a more precise alignment of cerebellar structures across participants compared to normalization using a whole-brain template. We also show the utility of the cerebellar mask to prevent contamination of cerebellar functional data from surrounding cortical structures. The toolbox also provides functionality for visualizing cerebellar data on a flatmap, along with a range of anatomical and functional cerebellar atlases, thereby offering an essential tool that enables accurate cerebellar analysis across the lifespan.