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Cross-layer semantic alignment and context enhancement network for medical image segmentation.

September 3, 2026pubmed logopapers

Authors

Liu B,Sun X,Zhan G

Affiliations (3)

  • School of Computer Science and Engineering, Shandong University of Science and Technology, No.579 Qianwan Harbor Road, Qingdao Economic & Technological Development Zone, Shandong Province, China, Qingdao, Qingdao, None Selected, 266590, China.
  • Shandong University of Science and Technology, No.579 Qianwan Harbor Road, Qingdao Economic & Technological Development Zone, Shandong Province, China, Qingdao, 266590, China.
  • Department of Spinal Surgery II, Qingdao Huangdao Central Hospital, Qingdao Huangdao Central Hospital, Qingdao, 266555, China.

Abstract

Medical image segmentation aims to accurately delineate organs, tissues, or lesion regions from complex medical images. However, existing hybrid models based on Transformers and convolutional neural networks (CNNs) still suffer from limitations in local detail modeling and cross-layer feature fusion, which often leads to blurred boundary information and loss of structural details. To address these issues, this paper proposes a Cross-layer Semantic Alignment and Context Enhancement Network (CSAE-Net) for medical image segmentation. Specifically, a semantic enhancement module is introduced into the skip connections to achieve effective fusion of high-level semantic information and shallow spatial details through spatial-channel collaborative modeling and multi-scale context extraction. In addition, a lightweight boundary refinement mechanism is employed in the decoder stage to improve the recovery capability for complex boundary regions. Experiments conducted on the Synapse, ACDC, and GlaS datasets demonstrate that the proposed method outperforms mainstream approaches in terms of Dice, HD95, and IoU metrics, validating the effectiveness of the cross-layer semantic alignment mechanism for complex medical image segmentation tasks.

Topics

Journal Article

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