A Deep Learning-Based Method for Automatic Registration of Craniofacial CBCT and Multi-planar Temporomandibular Joint MRI.
Authors
Affiliations (10)
Affiliations (10)
- Department of Oral and Maxillofacial-Head Neck Oncology, College of Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; No.639, Zhi-Zao-Ju Road, Shanghai 200011, People's Republic of China. Electronic address: [email protected].
- School of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai 201210, China.. Electronic address: [email protected].
- School of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai 201210, China.. Electronic address: [email protected].
- Department of Radiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.. Electronic address: [email protected].
- Department of Radiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.. Electronic address: [email protected].
- Department of Radiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.. Electronic address: [email protected].
- Department of Radiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
- School of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai 201210, China.. Electronic address: [email protected].
- Department of Oral and Maxillofacial-Head Neck Oncology, College of Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; No.639, Zhi-Zao-Ju Road, Shanghai 200011, People's Republic of China; National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai 200011, China.; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology 200011, Shanghai, China.. Electronic address: [email protected].
- Department of Radiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.. Electronic address: [email protected].
Abstract
To develop a fully automated multi-stage registration framework for temporomandibular joint (TMJ) imaging that enables spatial alignment between large-field-of-view cone-beam computed tomography (CBCT) and multi-planar small-field-of-view magnetic resonance imaging (MRI). The framework combined landmark-based rigid initial registration with nnU-Net-based mask-guided refinement registration. Four anatomical landmarks, including the most superior, medial, and lateral points and the gonion point, were automatically detected to estimate the initial rigid transformation between CBCT and MRI. Condylar segmentation masks were subsequently used to refine the local alignment. The segmentation performance was qualitatively and quantitatively evaluated using the Dice similarity coefficient, Intersection over Union, precision, and recall. Landmark localization accuracy was evaluated quantitatively using the modality-specific landmark localization error (LLE) against manually annotated landmarks, whereas the final registration results were qualitatively reviewed by a clinician experienced in TMJ imaging. The segmentation models showed high performance for automated condyle and articular disc segmentation. The mean LLE was 2.920 ± 1.460 mm for CBCT landmark localization and 3.520 ± 1.520 mm for MRI landmark localization. A qualitative review by a clinician suggested improved local anatomical alignment of the condyle and surrounding structures following mask-guided refinement. The proposed multi-stage framework enables automated registration between CBCT and multi-planar TMJ MRI by combining landmark-based coarse alignment and segmentation-mask-guided refinement registration. The proposed framework enables the automated spatial integration of CBCT-derived osseous information and MRI-derived soft tissue information, potentially facilitating comprehensive TMJ assessment while reducing the manual effort required for multimodal image alignment.