Updates in cardiovascular CT imaging in 2025: A year in review.
Authors
Affiliations (32)
Affiliations (32)
- Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. Electronic address: [email protected].
- Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
- Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, USA.
- Jabar AlAhmad Hospital, South Surra, Kuwait.
- Department of University Cardiology and Cardiac Imaging, IRCCS Ospedale Galeazzi Sant'Ambrogio, Milan, Italy; Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.
- Centro Cardiologico Monzino IRCCS, Milan, Italy.
- UT Southwestern Medical Center, Dallas, TX, USA.
- Division of Pediatric Cardiology, Atlantic Health Morristown Medical Center, Morristown, NJ, USA; Division of Pediatric Cardiology, Columbia University Irving Medical Center, New York, NY, USA.
- National Heart Lung and Blood Institute, NIH, Bethesda, MD, USA.
- IRCCS Ospedale Galeazzi Sant'Ambrogio, Milan, Italy.
- Emory University, Atlanta, GA, USA.
- Liverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool, UK.
- Oregon Health and Science University, Portland, OR, USA.
- Medical University of Innsbruck, Innsbruck, Austria.
- Charité - Universitätsmedizin Berlin, Berlin, Germany.
- Department of Cardiology, Rabin Medical Center, Petah Tikva, Israel; Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
- University of Utah, Salt Lake City, UT, USA.
- Victorian Heart Hospital, Clayton, Australia.
- University of British Columbia, Vancouver, BC, Canada.
- Bassett Medical Center, Cooperstown, NY, USA.
- Charité - Universitätsmedizin Berlin, Berlin, Germany; Mie University Graduate School of Medicine, Tsu, Japan.
- Department of Diagnostic Radiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
- Royal Brompton Hospital, London, UK; King's College London, London, UK.
- St. Luke's International Hospital, Tokyo, Japan.
- Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy; Centro Cardiologico Monzino IRCCS, Milan, Italy.
- University of Manchester, Manchester, UK.
- Royal Brompton Hospital, London, UK; King's College London, London, UK; University of Cambridge, Cambridge, UK.
- Johns Hopkins University School of Medicine, Baltimore, MD, USA.
- VA Long Beach Healthcare System, Long Beach, CA, USA.
- University of Edinburgh, Edinburgh, UK.
- University of Ottawa Heart Institute, Ottawa, ON, Canada.
- Yale School of Medicine, New Haven, CT, USA.
Abstract
The year 2025 brought long-term outcome data supporting coronary CT angiography (CCTA)-guided management of stable chest pain, a proposed reframing of coronary artery disease around atherosclerosis rather than ischemia, and the first large-scale real-world evaluation of a national artificial intelligence (AI)-enabled CT-derived fractional flow reserve (FFR-CT) program. This review summarizes selected advances in cardiovascular computed tomography (CCT) published in print or online during 2025. The studies span coronary artery disease outcomes and prevention, quantitative plaque analysis, photon-counting detector CT, coronary artery calcium scoring, pericoronary inflammation imaging, AI and machine learning, structural and congenital heart disease, and consensus and training documents. For each study we summarize the design, principal findings, limitations, and likely clinical implications, and we close with the barriers, including technical standardization, vendor-specific thresholds, equitable access, and the need for randomized outcome trials, that must be addressed before many of these advances can be implemented broadly.