Automated Body Composition from Computed Tomography Scans Improves Survival Prediction in Colorectal Cancer Patients.
Authors
Affiliations (7)
Affiliations (7)
- Department of Computer Science, Faculty of Science, Memorial University of Newfoundland, St. John's, NL, Canada. [email protected].
- Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
- School of Engineering, Simon Fraser University, Burnaby, BC, Canada.
- Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
- Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.
- Department of Internal Medicine Section of Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
- Department of Computer Science, Faculty of Science, Memorial University of Newfoundland, St. John's, NL, Canada.
Abstract
Colorectal cancer is one of the most common cancers, but the current staging system is limited by the variability and paradoxical survival outcomes. Body composition is an accurate predictor of survival and can be extracted from routine computed tomography (CT) scans used in cancer diagnosis. However, despite its potential, the adoption of body composition analysis has been limited due to the challenges in generating the data. In this study, we propose a deep learning-based model that combines clinical and body composition biomarkers to predict the survival of colorectal cancer patients. Our best model, which integrates both clinical and body composition features, achieved a time-dependent concordance-index score of 0.7298 ( <math xmlns="http://www.w3.org/1998/Math/MathML"><mrow><mi>p</mi> <mo><</mo> <mn>0.001</mn></mrow> </math> ), demonstrating a significant improvement over models based solely on clinical or body composition biomarkers, indicating that models combining body composition and clinical markers could improve survival prediction. Additionally, we observed that increased skeletal muscle tissue area and radiodensity were associated with reduced mortality risk, while higher radiodensities of visceral and subcutaneous adipose tissues were associated with increased risk.