AI CT model predicts HCC risk in cirrhosis with AUC up to 0.87

RadAISlice Newsletter

Weekly Updates in Radiology AI

Good morning, there. An AI-enhanced CT model stratified HCC risk in 2,411 cirrhosis patients with AUC up to 0.869.

AI-driven imaging risk tools could proactively identify patients likely to develop liver cancer, enabling earlier surveillance and tailored management. This large, multicenter study demonstrates externally validated benefit over standard models, supporting clinical adoption for HCC risk stratification. Integration of robust radiomics approaches in routine imaging may standardize and personalize oncologic care.

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Here's what you need to know about Radiology AI last week:

• AI-enhanced CT boosts HCC risk prediction for cirrhosis patients

• FDA requests radiologist input on real-world AI device safety

• False-positive findings differ between AI and radiologists in breast DBT

• Less than 30% of FDA-cleared radiology AI devices report preapproval safety data

• Plus: 10 newly released datasets, 5 FDA approved devices & 4 new papers.

🧬 AI-enhanced CT boosts HCC risk prediction for cirrhosis patients

Image from: EurekAlert

RadAISlice: A multicenter AI CT model stratifies hepatocellular carcinoma risk better than clinical criteria.

The details:

• 2,411 cirrhosis patients from multiple centers (2018–2023)

• All patients had 3-phase CT at baseline

• AI model AUC: 0.809–0.869, better than clinical models

• High-risk group: 26.3% HCC in 3 years; low-risk: 1.7%

• Identified 7% of patients with very-high risk of HCC

Key takeaway: Robust CT-based AI models can personalize HCC surveillance, identifying high-risk and low-risk cirrhosis patients more accurately than current clinical models.

📋 FDA requests radiologist input on real-world AI device safety

Image from: AI in Healthcare

RadAISlice: FDA opens public comment for monitoring AI in radiology and medical imaging devices.

The details:

• Comment window: Sept 30–Dec 1 for real-world device monitoring

• Focus on detection/mitigation of data and model drift

• Most FDA evaluations rely on static, retrospective testing

• User feedback sought to boost clinical safety of AI tools

Key takeaway: Broader post-market surveillance and radiologist feedback are key to maintaining AI imaging tool safety and effectiveness as adoption increases.

🧩 False-positive findings differ between AI and radiologists in breast DBT

RadAISlice: Head-to-head study shows different false positive profiles for AI vs radiologists in breast DBT.

The details:

• Sample: 2,977 women, 3,183 exams (2013–2017)

• False-positive rates nearly identical (9.7% AI vs 9.5% radiologist)

• AI-only: more benign calcifications; radiology-only: more masses

• Concordant findings high-risk in 44% of biopsies

Key takeaway: Knowing which findings trigger false positives for AI vs radiologists can guide tool improvement, reduce unnecessary recalls, and optimize breast cancer screening.

📝 Less than 30% of FDA-cleared radiology AI devices report preapproval safety data

Image from: Radiology Business

RadAISlice: Systematic review exposes a gap in safety reporting for AI radiology devices cleared by the FDA.

The details:

• Reviewed 691 AI/ML devices (1995–2023); 531 in radiology

• <30% provided safety, efficacy, or adverse event data

• No predefined safety or efficacy standards for AI/ML devices in US

• Calls for stricter approval/testing for imaging AI devices

Key takeaway: Regulatory transparency and robust safety data reporting must improve for FDA-cleared AI radiology devices to maintain patient trust and safe implementation.

CardioBench (2025-10-01)

Modality: US | Focus: Cardiac, pediatric | Task: Regression, classification

• Size: Data from 8 datasets: >40,000 echo videos/images, >30,000 patients

• Annotations: Regression (ejection fraction, chamber dimensions, wall thickness); classification (disease, pathology, view); expert and automated labels

• Institutions: MBZUAI, Stanford AIMI et al.

• Availability:

  public + request-only (partial) https://anonymous.4open.science/r/CardioBench/

• Highlight: First standardized benchmark aggregating 8 open echo datasets for multi-task, multi-view echocardiography AI

MedQ-Bench (2025-10-02)

Modality: CT, MRI, X-ray, Endoscopy, Fundus, Histopathology | Focus: multi-organ, general body regions | Task: quality assessment, visual reasoning

• Size: 3,308 images, 5 modalities, multi-source, balanced by task/degradation

• Annotations: Multi-type: perception (MCQA with Yes/No, What, How Q&A), detailed expert-written quality reasoning, pairwise comparison labels

• Institutions: Fudan University, Shanghai Artificial Intelligence Laboratory, et al.

• Availability:

  Public (github.com/liujiyaoFDU/MedQBench)

• Highlight: First benchmark for human-like reasoning and perception in medical image quality across 5 modalities with expert-aligned annotation.

SpurBreast (2025-10-02)

Modality: MRI | Focus: Breast | Task: Classification, Generalization Robustness

• Size: 900+ 3D scans, 900+ patients; 250 slices per scan

• Annotations: Tumor presence (slices labeled positive/negative); 100+ patient and imaging metadata features

• Institutions: Ghent University Global Campus, IDLab Ghent University et al.

• Availability:

  public (github.com/utkuozbulak/spurbreast)

• Highlight: Curated real breast MRI datasets with controlled spurious correlations for bias and robustness research

Hemorica (2025-09-26)

Modality: CT | Focus: Brain | Task: Classification, Segmentation

• Size: 372 head CT scans, 372 patients, 12,067 slices

• Annotations: Five ICH subtypes with patient- and slice-level labels, bounding boxes, 2D and 3D segmentation masks

• Institutions: Rasoul Akram Hospital, K.N. Toosi University of Technology

• Availability:

  public (link)

• Highlight: Fine-grained public dataset: subtype, masks, boxes, consensus annotation for ICH.

ViMed-PET (2025-09-29)

Modality: PET/CT | Focus: Whole body (oncology), Lung | Task: Report generation, VQA

• Size: 1,567,062 scans, 2,757 patients

• Annotations: Full-length Vietnamese clinical reports; expert-curated lung cancer test set with structured labels

• Institutions: Hanoi University of Science and Technology, 108 Military Central Hospital et al.

• Availability:

  Non-public

• Highlight: First large-scale paired PET/CT-reports dataset in Vietnamese; rich multimodal and multilingual resource

MetaChest (2025-10-01)

Modality: X-ray | Focus: Chest, Lungs | Task: Classification, Few-shot learning

• Size: 479,215 chest X-ray images from 322,475 patients

• Annotations: Multi-label pathology annotations for 15 common chest diseases

• Institutions: Instituto de Investigaciones en Matemáticas Aplicadas y en Sistemas, UNAM et al.

• Availability:

  Public, https://github.com/bereml/metachest

• Highlight: Largest chest X-ray few-shot/meta-learning benchmark; unified meta-set with algorithmic episode generation

LMOD+ (2025-09-30)

Modality: CFP, SLO, OCT, LP, SS | Focus: Retina, Lens | Task: Classification, Segmentation

• Size: 32,633 images; 10 datasets; over 11,000 patients (estimated, varies by source); 5 modalities

• Annotations: Multi-granular labels: disease diagnosis, disease stage, anatomical region bounding boxes, demographics (age, sex), free text

• Institutions: Yale University, Australian National University et al.

• Availability:

  Public (link to be announced)

• Highlight: Largest, most diverse multimodal benchmark for AI in ophthalmology; tasks include diagnosis, staging, anatomical structure, and demographic prediction.

BreastDCEDL AMBL (2025-05-30)

Modality: MRI | Focus: Breast | Task: Classification, Segmentation

• Size: 133 lesions (89 benign, 44 malignant) from 88 patients

• Annotations: Manual lesion segmentations (benign and malignant), NIfTI masks

• Institutions: Ariel University, The Cancer Imaging Archive (TCIA)

• Availability:

  public (zenodo link)

• Highlight: First public DCE-MRI dataset with both benign and malignant lesion annotations; supports benchmarking benign-malignant classification.

TEMMED-BENCH (2025-09-29)

Modality: X-ray | Focus: Chest | Task: Temporal reasoning, VQA

• Size: 18,144 image pairs from 9,072 patients; test set: 1,000 cases

• Annotations: Report labels describing condition change, VQA (yes/no), image-pair selection

• Institutions: University of California Los Angeles, Amazon

• Availability:

  public https://TemMedBench.github.io

• Highlight: First benchmark for temporal medical image reasoning; real-world, multi-visit chest X-ray pairs

Neural-MedBench (2025-09-26)

Modality: MRI, CT | Focus: brain, neurology | Task: clinical reasoning, diagnosis

• Size: 120 cases, 200 tasks, 120 patients

• Annotations: expert-curated diagnoses, reasoning justifications, lesion labels

• Institutions: Guangdong Institute of Intelligence Science and Technology, Beijing Chaoyang Hospital et al.

• Availability:

  public (HuggingFace link)

• Highlight: Multimodal, reasoning-intensive neurology cases with structured justifications; designed as a high-density stress test for clinical reasoning in AI.

🏛️ FDA Clearances

• K251483 - SwiftSight-Brain by AIRS Medical Inc. (510k) aids radiologists with automatic brain image analysis for diagnostic support.

• K251527 - Brain WMH (Quantib BV, 510k) automates white matter hyperintensity segmentation on brain MRI for lesion quantification.

• K251987 - Rapid Aortic Measurements (iSchemaView, 510k) uses CT to segment and measure the aorta, supporting aortic dissection diagnosis.

• K252105 - Ligence Heart (Ligence, UAB, 510k) enables AI-driven cardiac segmentation and quantification from CT imaging.

• K250045 - uWS-Angio Pro (United Imaging, 510k) processes multimodal angiographic images—image synthesis and quantitative vessel analysis.

• Explore last week's 10 radiology AI FDA approvals.

📄 Fresh Papers

• doi:10.1186/s12911-025-03193-3 - Multicenter study develops and validates interpretable deep learning and nomogram for grading PNETs using EUS images with high AUC and clinical utility.

• doi:10.1038/s43587-025-00962-7 - Genome-wide study in 56,348 individuals links 59 loci to MRI-predicted brain 'age gap' and ties high blood pressure and diabetes to accelerated brain aging.

• doi:10.1097/RLI.0000000000001186 - Real-world, prospective study shows DL super-resolution cine cardiac MRI halves exam time and matches standard cine quality, even with arrhythmia.

• doi:10.1016/j.ultrasmedbio.2025.09.002 - Meta-analysis finds MRI radiomics models predict HIFU efficacy in uterine fibroids (AUC=0.84), but notes data/reporting gaps limit generalizability.

• Browse 258 new radiology AI studies from last week.

📰 Everything else in Radiology AI last week

• AI using multiphoton microscopy images classifies pancreatic neuroendocrine neoplasms with up to 96% accuracy in a multicenter study.

• AI tool detects ≥5% fibrosis progression on serial CT scans, doubling risk of death or transplant in fibrotic lung disease.

• CT imaging and RNA sequencing reveal glioblastoma causes skull erosion and shifts marrow immunity—potential systemic impact for radiology and therapy.

• UCLA's photonics generative AI system leaves environmental footprint smaller than digital models and creates images in a single step.

• New study finds higher patient BMI increases noise and complexity, reducing both AI and radiologist accuracy in low-dose chest CT interpretation.

• Read 22 fresh radiology AI news articles for last week.

That's it for today!

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